Fenbendazole is a very safe drug that is often used to treat parasites in cats and dogs. It has recently been reported to have anticancer effects in humans.
It was shown to inhibit growth of human lymphoma xenografted into scid mice. This was thought to be due to both a direct effect on the tumor cells and a stimulation of host immune responses. These studies indicate that fenbendazole may have useful anticancer activity in combination with different tumor treatment regimens, including surgery, radiation and chemotherapy.
Fenbendazole is believed to act by blocking microtubule production. Microtubules are essential to cell structure and have many functions including mitosis (cell division) and apoptosis (cell death). In apoptosis, the microtubules are broken and the mitochondria depolarize to allow the death signal to be released. Fenbendazole works by targeting the phosphate groups on the tubulin dimer, and therefore interferes with microtubule function.
Interestingly, research is ongoing on a similar class of drugs, called benzimidazole antihelmintics. These are commonly used animal worm medications and are also under investigation as potential cancer treatments. While these drugs have shown promise, converting them into an approved medication takes years.
Until there is a better option, fenbendazole may be worth considering in conjunction with other scientifically proven treatments such as vitamin E, curcumin and CBD oil. It is important to remember that any treatment plan needs to be monitored closely by your veterinarian. It is recommended to stay with the prescribed dose, even if your pet feels better, until the treatment is completely finished. This will prevent relapse and resistance. fenbendazole 222mg capsules for humans