Fenbendazole is a dewormer medication that has shown to have cancer-fighting properties in some cases. It works by disrupting cancer cell division and preventing them from accessing sugar. It also boosts p53 levels, which are needed to keep cancer cells in check. It is a member of the benzimidazole family of drugs, which has been in use as anthelmintics for decades.
The fenbendazole protocol has gained popularity in recent years after some remarkable success stories. This protocol uses a combination of fenbendazole (Panacur C) and supplements to treat various types of cancer.
Fenben is a member of the benzimidazole family and has been shown to have antitumor activity in human cell lines. Specifically, it is able to disrupt microtubules (MT) and induce apoptosis in cells. This is accomplished by binding to the MT tubulin and inhibiting its polymerization, which results in a loss of cellular stability. MTs play a critical role in cell division and motility, as well as the transport of organelles, the maintenance of the cell shape, and energy management processes.
Interestingly, it was found that fenbendazole is particularly effective in hepatocellular carcinoma (HCC) cell lines. The pharmacological effect of this compound is attributed to its ability to target and bind the protein p53, leading to a cascade of events that ultimately leads to cell death. In addition, fenbendazole has been shown to inhibit the growth of HCC cells by upregulating p21 and downregulating cyclins B and D in G1/S phase. This resulted in the depletion of glycogen and apoptosis of tumor cells.
As a result, more research is needed to determine whether this drug can help treat cancer in humans. However, the fact that it is an existing medicine with a long track record of safety in humans means it could be an excellent candidate for repurposing as an antitumor agent.
For example, an anecdotal case was published of a man who claimed that he was cured of his small-cell lung cancer by taking fenbendazole along with conventional chemotherapy and radiation. While his experience was interesting, it’s worth noting that this type of anecdotal evidence isn’t a reliable way to establish a new treatment protocol. In order to do so, randomized controlled trials involving many patients would need to be conducted.
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